Synthesis of drug molecules for life threatening diseases is the field of future which is profitable to the individual as well as the nation. To achieve this purpose, development of novel greener methods that are widely applicable and serve to expand familiar methodological devices in the synthetic arsenal is highly desirable. In this regard, a number of methods such as domino reactions, multicomponent reactions, transition metal catalysed reactions, organocatalysis and catalysis using efficient materials have extensively been explored. In homogeneous catalysis, one of the recent topic of interest refers to the explicit alteration of C-H into C-C bonds, which is arguably imperative in modern experimental chemistry, as it concede for yielding target compounds which are otherwise only reachable via lengthy strategies implicating multi-step synthesis. Catalytic C-H functionalization is the most enticing approach to attain this goal, as it does not require stoichiometric amounts of activating reagent and delivers less waste as side product. Our research aims to develop novel methods on C-H activation, Asymmetric catalysis, organo-catalysis, cooperative dual catalysis, frustrated Lewis Pairs etc.